Make it work with virtualenv

Is this possible? Add a config file to be able to insert a working dir and path?

It'll find your virtualenv as long as the virtualenv's bin directory is somewhere in the parent folders of the file. If you've got your virtualenv somewhere else, then adding a way to configure that via a setting in a .sublime-project file sounds like a good idea. I don't have time/need to implement that myself but I'll review a pull request.