diff --git a/packages/react-native/scripts/cocoapods/__tests__/new_architecture-test.rb b/packages/react-native/scripts/cocoapods/__tests__/new_architecture-test.rb
index 6a7d5f7cb8b..c5cadd975d5 100644
--- a/packages/react-native/scripts/cocoapods/__tests__/new_architecture-test.rb
+++ b/packages/react-native/scripts/cocoapods/__tests__/new_architecture-test.rb
@@ -524,16 +524,20 @@ def prepare_installer_for_cpp_flags(xcconfigs, build_configs)
     end
 
     pod_target_installation_results_map = {}
+    user_build_configuration_map = {}
     build_configs.each do |name, build_configs|
         pod_target_installation_results_map[name.to_s] = prepare_pod_target_installation_results_mock(
             name.to_s, build_configs
         )
+        build_configs.each do |config|
+            user_build_configuration_map[config.name] = config
+        end
     end
 
     return InstallerMock.new(
         PodsProjectMock.new,
         [
-            AggregatedProjectMock.new(:xcconfigs => xcconfigs_map, :base_path => "a/path/")
+            AggregatedProjectMock.new(:xcconfigs => xcconfigs_map, :base_path => "a/path/", :user_build_configurations => user_build_configuration_map)
         ],
         :pod_target_installation_results => pod_target_installation_results_map
     )
diff --git a/packages/react-native/scripts/cocoapods/__tests__/test_utils/InstallerMock.rb b/packages/react-native/scripts/cocoapods/__tests__/test_utils/InstallerMock.rb
index c06cb592e0a..318c349cacf 100644
--- a/packages/react-native/scripts/cocoapods/__tests__/test_utils/InstallerMock.rb
+++ b/packages/react-native/scripts/cocoapods/__tests__/test_utils/InstallerMock.rb
@@ -96,13 +96,15 @@ def save()
 class AggregatedProjectMock
     attr_reader :user_project
     attr_reader :xcconfigs
+    attr_reader :user_build_configurations
 
     @base_path
 
-    def initialize(user_project = UserProjectMock.new, xcconfigs: {}, base_path: "")
+    def initialize(user_project = UserProjectMock.new, xcconfigs: {}, base_path: "", user_build_configurations: {})
         @user_project = user_project
         @xcconfigs = xcconfigs
         @base_path = base_path
+        @user_build_configurations = user_build_configurations
     end
 
     def xcconfig_path(config_name)
@@ -199,7 +201,7 @@ def debug?
     end
 
     def type
-        @is_debug ? :debug : :release
+        return @is_debug ? :debug : :release
     end
 end
 
diff --git a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
index 821a702bcad..28b01500840 100644
--- a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
+++ b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
@@ -1153,19 +1153,21 @@ def test_add_flag_to_map_with_inheritance_whenUsedWithArrayAttributes
     def test_add_ndebug_flag_to_pods_in_release
         # Arrange
         xcconfig = XCConfigMock.new("Config")
-        default_debug_config = BuildConfigurationMock.new("Debug")
-        default_release_config = BuildConfigurationMock.new("Release")
-        custom_debug_config1 = BuildConfigurationMock.new("CustomDebug")
-        custom_debug_config2 = BuildConfigurationMock.new("Custom")
-        custom_release_config1 = BuildConfigurationMock.new("CustomRelease")
-        custom_release_config2 = BuildConfigurationMock.new("Production")
+        default_debug_config = BuildConfigurationMock.new("Debug", {}, is_debug: true)
+        default_release_config = BuildConfigurationMock.new("Release", {}, is_debug: false)
+        custom_debug_config1 = BuildConfigurationMock.new("CustomDebug", {}, is_debug: true)
+        custom_debug_config2 = BuildConfigurationMock.new("Custom", {}, is_debug: true)
+        custom_release_config1 = BuildConfigurationMock.new("CustomRelease", {}, is_debug: false)
+        custom_release_config2 = BuildConfigurationMock.new("Production", {}, is_debug: false)
+        custom_release_config3 = BuildConfigurationMock.new("Main", {}, is_debug: false)
 
         installer = prepare_installer_for_cpp_flags(
             [ xcconfig ],
             {
                 "Default" => [ default_debug_config, default_release_config ],
                 "Custom1" => [ custom_debug_config1, custom_release_config1 ],
-                "Custom2" => [ custom_debug_config2, custom_release_config2 ]
+                "Custom2" => [ custom_debug_config2, custom_release_config2 ],
+                "Custom3" => [ custom_release_config3 ],
             }
         )
         # Act
@@ -1178,6 +1180,7 @@ def test_add_ndebug_flag_to_pods_in_release
         assert_equal("$(inherited) -DNDEBUG", custom_release_config1.build_settings["OTHER_CPLUSPLUSFLAGS"])
         assert_equal(nil, custom_debug_config2.build_settings["OTHER_CPLUSPLUSFLAGS"])
         assert_equal("$(inherited) -DNDEBUG", custom_release_config2.build_settings["OTHER_CPLUSPLUSFLAGS"])
+        assert_equal("$(inherited) -DNDEBUG", custom_release_config3.build_settings["OTHER_CPLUSPLUSFLAGS"])
     end
 end
 
@@ -1234,16 +1237,20 @@ def prepare_installer_for_cpp_flags(xcconfigs, build_configs)
     end
 
     pod_target_installation_results_map = {}
+    user_build_configuration_map = {}
     build_configs.each do |name, build_configs|
         pod_target_installation_results_map[name.to_s] = prepare_pod_target_installation_results_mock(
             name.to_s, build_configs
         )
+        build_configs.each do |config|
+            user_build_configuration_map[config.name] = config
+        end
     end
 
     return InstallerMock.new(
         PodsProjectMock.new,
         [
-            AggregatedProjectMock.new(:xcconfigs => xcconfigs_map, :base_path => "a/path/")
+            AggregatedProjectMock.new(:xcconfigs => xcconfigs_map, :base_path => "a/path/", :user_build_configurations => user_build_configuration_map)
         ],
         :pod_target_installation_results => pod_target_installation_results_map
     )
diff --git a/packages/react-native/scripts/cocoapods/utils.rb b/packages/react-native/scripts/cocoapods/utils.rb
index 4ce64600cb1..9cf9eeac260 100644
--- a/packages/react-native/scripts/cocoapods/utils.rb
+++ b/packages/react-native/scripts/cocoapods/utils.rb
@@ -664,7 +664,7 @@ def self.add_ndebug_flag_to_pods_in_release(installer)
 
         installer.aggregate_targets.each do |aggregate_target|
             aggregate_target.xcconfigs.each do |config_name, config_file|
-                is_release = config_name.downcase.include?("release") || config_name.downcase.include?("production")
+                is_release = aggregate_target.user_build_configurations[config_name] == :release
                 unless is_release
                     next
                 end
@@ -678,7 +678,7 @@ def self.add_ndebug_flag_to_pods_in_release(installer)
 
         installer.target_installation_results.pod_target_installation_results.each do |pod_name, target_installation_result|
             target_installation_result.native_target.build_configurations.each do |config|
-                is_release = config.name.downcase.include?("release") || config.name.downcase.include?("production")
+                is_release = config.type == :release
                 unless is_release
                     next
                 end