diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000000..1c625c6d22
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,61 @@
+[build-system]
+requires = ["setuptools", "setuptools-scm"]
+build-backend = "setuptools.build_meta"
+
+[project]
+name = "httpx"
+description = "The next generation HTTP client."
+authors = [{ name = "Tom Christie", email = "tom@tomchristie.com" }]
+license = { text = "BSD 3-Clause License" }
+requires-python = ">=3.7"
+dependencies = [
+    "certifi",
+    "sniffio",
+    "rfc3986[idna2008]>=1.3,<2",
+    "httpcore>=0.15.0,<0.16.0",
+]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Environment :: Web Environment",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: BSD License",
+    "Operating System :: OS Independent",
+    "Topic :: Internet :: WWW/HTTP",
+    "Framework :: AsyncIO",
+    "Framework :: Trio",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3 :: Only",
+]
+dynamic = ["version", "readme"]
+
+[tool.setuptools]
+license-files = ["LICENSE.md"]
+package-data = { "httpx" = ["py.typed"] }
+include-package-data = true
+zip-safe = false
+
+[project.optional-dependencies]
+http2 = ["h2>=3,<5"]
+socks = ["socksio==1.*"]
+brotli = [
+    "brotli; platform_python_implementation == 'CPython'",
+    "brotlicffi; platform_python_implementation != 'CPython'",
+]
+cli = ["click==8.*", "rich>=10,<13", "pygments==2.*"]
+
+[project.urls]
+Homepage = "https://www.python-httpx.org"
+Changelog = "https://github.com/encode/httpx/blob/master/CHANGELOG.md"
+Documentation = "https://www.python-httpx.org"
+Source = "https://github.com/encode/httpx"
+
+[project.scripts]
+httpx = "httpx:main"
+
+[tool.setuptools.dynamic]
+version = { attr = "httpx.__version__.__version__" }
+readme = { file = ["README.md", "CHANGELOG.md"], content-type = "text/markdown" }
diff --git a/requirements.txt b/requirements.txt
index dbbc7f3b63..1aa7cbb451 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -17,6 +17,7 @@ mkdocs-material==8.3.8
 # Packaging
 twine==4.0.1
 wheel==0.37.1
+build==0.8.0
 
 # Tests & Linting
 autoflake==1.4
diff --git a/scripts/build b/scripts/build
index 1c47d2cc2a..92378cb942 100755
--- a/scripts/build
+++ b/scripts/build
@@ -8,6 +8,6 @@ fi
 
 set -x
 
-${PREFIX}python setup.py sdist bdist_wheel
+${PREFIX}python -m build
 ${PREFIX}twine check dist/*
 ${PREFIX}mkdocs build
diff --git a/setup.py b/setup.py
index 0fdbd03ced..15dc6ac2bc 100644
--- a/setup.py
+++ b/setup.py
@@ -1,96 +1,5 @@
-#!/usr/bin/env python
-# -*- coding: utf-8 -*-
-
-import re
-from pathlib import Path
-
+# This file is needed for editable installs.
+# Ref.: https://setuptools.pypa.io/en/latest/userguide/pyproject_config.html
 from setuptools import setup
 
-
-def get_version(package):
-    """
-    Return package version as listed in `__version__` in `init.py`.
-    """
-    version = Path(package, "__version__.py").read_text()
-    return re.search("__version__ = ['\"]([^'\"]+)['\"]", version).group(1)
-
-
-def get_long_description():
-    """
-    Return the README.
-    """
-    long_description = ""
-    with open("README.md", encoding="utf8") as f:
-        long_description += f.read()
-    long_description += "\n\n"
-    with open("CHANGELOG.md", encoding="utf8") as f:
-        long_description += f.read()
-    return long_description
-
-
-def get_packages(package):
-    """
-    Return root package and all sub-packages.
-    """
-    return [str(path.parent) for path in Path(package).glob("**/__init__.py")]
-
-
-setup(
-    name="httpx",
-    python_requires=">=3.7",
-    version=get_version("httpx"),
-    url="https://github.com/encode/httpx",
-    project_urls={
-        "Changelog": "https://github.com/encode/httpx/blob/master/CHANGELOG.md",
-        "Documentation": "https://www.python-httpx.org",
-        "Source": "https://github.com/encode/httpx",
-    },
-    license="BSD",
-    description="The next generation HTTP client.",
-    long_description=get_long_description(),
-    long_description_content_type="text/markdown",
-    author="Tom Christie",
-    author_email="tom@tomchristie.com",
-    package_data={"httpx": ["py.typed"]},
-    packages=get_packages("httpx"),
-    include_package_data=True,
-    zip_safe=False,
-    install_requires=[
-        "certifi",
-        "sniffio",
-        "rfc3986[idna2008]>=1.3,<2",
-        "httpcore>=0.15.0,<0.16.0",
-    ],
-    extras_require={
-        "http2": "h2>=3,<5",
-        "socks": "socksio==1.*",
-        "brotli": [
-            "brotli; platform_python_implementation == 'CPython'",
-            "brotlicffi; platform_python_implementation != 'CPython'"
-        ],
-        "cli": [
-            "click==8.*",
-            "rich>=10,<13",
-            "pygments==2.*"
-        ]
-    },
-    entry_points = {
-        "console_scripts": "httpx=httpx:main"
-    },
-    classifiers=[
-        "Development Status :: 4 - Beta",
-        "Environment :: Web Environment",
-        "Intended Audience :: Developers",
-        "License :: OSI Approved :: BSD License",
-        "Operating System :: OS Independent",
-        "Topic :: Internet :: WWW/HTTP",
-        "Framework :: AsyncIO",
-        "Framework :: Trio",
-        "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.7",
-        "Programming Language :: Python :: 3.8",
-        "Programming Language :: Python :: 3.9",
-        "Programming Language :: Python :: 3.10",
-        "Programming Language :: Python :: 3 :: Only",
-    ],
-)
+setup()