diff --git a/MANIFEST.in b/MANIFEST.in
deleted file mode 100644
index f124a4c6c..000000000
--- a/MANIFEST.in
+++ /dev/null
@@ -1,4 +0,0 @@
-include README.md
-include CHANGELOG.md
-include LICENSE.md
-include httpcore/py.typed
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 000000000..07187d0b5
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,68 @@
+[build-system]
+requires = ["hatchling", "hatch-fancy-pypi-readme"]
+build-backend = "hatchling.build"
+
+[project]
+name = "httpcore"
+dynamic = ["readme", "version"]
+description = "A minimal low-level HTTP client."
+license = "BSD-3-Clause"
+requires-python = ">=3.7"
+authors = [
+    { name = "Tom Christie", email = "tom@tomchristie.com" },
+]
+classifiers = [
+    "Development Status :: 3 - Alpha",
+    "Environment :: Web Environment",
+    "Framework :: AsyncIO",
+    "Framework :: Trio",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: BSD License",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3 :: Only",
+    "Programming Language :: Python :: 3.7",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3.11",
+    "Topic :: Internet :: WWW/HTTP",
+]
+dependencies = [
+    "anyio>=3.0,<5.0",
+    "certifi",
+    "h11>=0.13,<0.15",
+    "sniffio==1.*",
+]
+
+[project.optional-dependencies]
+http2 = [
+    "h2>=3,<5",
+]
+socks = [
+    "socksio==1.*",
+]
+
+[project.urls]
+Documentation = "https://www.encode.io/httpcore"
+Homepage = "https://www.encode.io/httpcore/"
+Source = "https://github.com/encode/httpcore"
+
+[tool.hatch.version]
+path = "httpcore/__init__.py"
+
+[tool.hatch.build.targets.sdist]
+include = [
+    "/httpcore",
+    "/CHANGELOG.md",
+    "/README.md",
+]
+
+[tool.hatch.metadata.hooks.fancy-pypi-readme]
+content-type = "text/markdown"
+
+[[tool.hatch.metadata.hooks.fancy-pypi-readme.fragments]]
+path = "README.md"
+
+[[tool.hatch.metadata.hooks.fancy-pypi-readme.fragments]]
+path = "CHANGELOG.md"
diff --git a/requirements.txt b/requirements.txt
index 78b85e60c..1884c090b 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -12,8 +12,8 @@ mkdocstrings[python-legacy]==0.22.0
 jinja2==3.1.2
 
 # Packaging
+build==0.10.0
 twine
-wheel
 
 # Tests & Linting
 anyio==3.6.2
diff --git a/scripts/build b/scripts/build
index 602eab0a4..657ded044 100755
--- a/scripts/build
+++ b/scripts/build
@@ -10,6 +10,6 @@ fi
 
 set -x
 
-${PREFIX}python setup.py sdist bdist_wheel
+${PREFIX}python -m build
 ${PREFIX}twine check dist/*
 ${PREFIX}mkdocs build
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 2e2ef37a7..000000000
--- a/setup.py
+++ /dev/null
@@ -1,83 +0,0 @@
-#!/usr/bin/env python
-# -*- coding: utf-8 -*-
-
-import re
-from pathlib import Path
-
-from setuptools import setup
-
-
-def get_version(package):
-    """
-    Return package version as listed in `__version__` in `init.py`.
-    """
-    version = Path(package, "__init__.py").read_text()
-    return re.search("__version__ = ['\"]([^'\"]+)['\"]", version).group(1)
-
-
-def get_long_description():
-    """
-    Return the README.
-    """
-    long_description = ""
-    with open("README.md", encoding="utf8") as f:
-        long_description += f.read()
-    long_description += "\n\n"
-    with open("CHANGELOG.md", encoding="utf8") as f:
-        long_description += f.read()
-    return long_description
-
-
-def get_packages(package):
-    """
-    Return root package and all sub-packages.
-    """
-    return [str(path.parent) for path in Path(package).glob("**/__init__.py")]
-
-
-setup(
-    name="httpcore",
-    python_requires=">=3.7",
-    version=get_version("httpcore"),
-    url="https://github.com/encode/httpcore",
-    project_urls={
-        "Documentation": "https://www.encode.io/httpcore",
-        "Source": "https://github.com/encode/httpcore",
-    },
-    license="BSD",
-    description="A minimal low-level HTTP client.",
-    long_description=get_long_description(),
-    long_description_content_type="text/markdown",
-    author="Tom Christie",
-    author_email="tom@tomchristie.com",
-    packages=get_packages("httpcore"),
-    include_package_data=True,
-    zip_safe=False,
-    install_requires=[
-        "h11>=0.13,<0.15",
-        "sniffio==1.*",
-        "anyio>=3.0,<5.0",
-        "certifi",
-    ],
-    extras_require={
-        "http2": ["h2>=3,<5"],
-        "socks": ["socksio==1.*"]
-    },
-    classifiers=[
-        "Development Status :: 3 - Alpha",
-        "Environment :: Web Environment",
-        "Intended Audience :: Developers",
-        "License :: OSI Approved :: BSD License",
-        "Operating System :: OS Independent",
-        "Topic :: Internet :: WWW/HTTP",
-        "Framework :: AsyncIO",
-        "Framework :: Trio",
-        "Programming Language :: Python :: 3",
-        "Programming Language :: Python :: 3.7",
-        "Programming Language :: Python :: 3.8",
-        "Programming Language :: Python :: 3.9",
-        "Programming Language :: Python :: 3.10",
-        "Programming Language :: Python :: 3.11",
-        "Programming Language :: Python :: 3 :: Only",
-    ],
-)